The Biological Significance of PLK1 in Cancer Polo-like kinase 1 (PLK1) is a key regulator of the cell cycle, particularly controlling mitotic entry, spindle assembly, centrosome maturation, and cytokinesis. While PLK1 is tightly regulated in normal cells, it is frequently overexpressed in cancers such as breast, lung, colorectal, and prostate, driving unchecked cellular proliferation. Elevated...